临床试验设计
院外心脏骤停患者神经功能不良预后的评分系统的开发与验证
doi:10.1093/eurheartj/ehaa570
本研究是针对院外心脏骤停（OOHCA）事件，进行早期预测患者结局有助于医师进行临床决策。虽然针对该类患者预后预测已有CAHP及TTM评分管理系统，但两种评分系统变量组成复杂，紧急状态下使用受限。
结论：MIRACLE2评分运用简单的入院临床指标，为院外心脏骤停的患者不良神经功能结局提供了早期准确预测，具有良好的临床使用价值。
- 收集373例患者，进行临床指标分析，其生存预后效果。建立MIRACLE2评分系统。
- 在外部队列，进行验证MIRACLE2评分系统。
核心
采用机器学习方法，建立预测模型，导入患者信息，shiny显示结果。摈弃繁杂的评分计算，考虑变量的非线性关系。
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